Prediction of functional recovery after revascularization in patients with chronic ischaemic left ventricular dysfunction

Autor: Pieter L. Jager, Riemer H. J. A. Slart, Wim J. Sluiter, Jaep de Boer, Jeroen J. Bax, Rudi Dierckx, Roy Irwan, Dirk J. van Veldhuisen, Ernst E. van der Wall
Přispěvatelé: Cardiovascular Centre (CVC), Vascular Ageing Programme (VAP), Translational Immunology Groningen (TRIGR)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
medicine.medical_treatment
EMISSION COMPUTED-TOMOGRAPHY
Coronary Artery Disease
Single-photon emission computed tomography
Isotopes of technetium
Ventricular Dysfunction
Left
ISOTOPE SIMULTANEOUS-ACQUISITION
Technetium-99
PERFUSION
FLUORINE-18-FDG SPECT
FDG-SPECT
Coronary Artery Bypass
medicine.diagnostic_test
General Medicine
Prognosis
ATTENUATION CORRECTION
Treatment Outcome
Cardiology
Female
DISA SPECT
Perfusion
Technetium Tc 99m Sestamibi
medicine.medical_specialty
IMPROVEMENT
myocardial viability
Revascularization
Sensitivity and Specificity
Ammonium Chloride
Fluorodeoxyglucose F18
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
In patient
DYSSYNERGIC MYOCARDIUM
Aged
Tomography
Emission-Computed
Single-Photon
Nitrogen Radioisotopes
business.industry
Reproducibility of Results
Recovery of Function
Functional recovery
PET
Positron-Emission Tomography
LV dysfunction
DOBUTAMINE ECHOCARDIOGRAPHY
Radiopharmaceuticals
Nuclear medicine
business
Emission computed tomography
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging, 33(6), 716-723. SPRINGER
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-005-0016-z
Popis: Purpose: F-18-FDG PET is an important modality for myocardial viability assessment in patients with left ventricular (LV) dysfunction. Dual-isotope simultaneous acquisition (DISA) SPECT may be an alternative to PET. The aim of this study was to compare the diagnostic performance of PET and DISA SPECT for the prediction of improvement in regional and global LV function as well as LV reverse remodelling after revascularization.Methods: Patients (n= 47) with chronic coronary artery disease and LV dysfunction underwent DISA SPECT ( with Tc-99m-sestamibi and F-18-FDG) and PET ( with N-13-ammonia and F-18-FDG) on the same day to assess viability. All patients underwent revascularization and recovery of function was derived from serial magnetic resonance imaging studies.Results: Of 264 revascularized, dysfunctional segments, 143 (54%) improved in function. For prediction of improvement in regional LV function, PET and DISA SPECT had similar sensitivity (90% versus 89%, NS) and specificity (86% versus 86%, NS). For prediction of improvement in global LV function, sensitivity was 83% for DISA SPECT and 86% for PET (p= NS), whereas both modalities had a specificity of 100%. Finally, sensitivity and specificity for the prediction of LV reverse remodelling were also similar for DISA SPECT and PET.Conclusion: In patients undergoing revascularization, DISA SPECT and PET predict the improvement in regional and global LV function and LV remodelling equally well post revascularization.
Databáze: OpenAIRE
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