Hemodynamics effects of adrecizumab in sepsis rat
| Autor: | C Bernard, Malha Sadoune, Evelyne Polidano, Alice Blet, Jane-Lyse Samuel, Régine Merval, Alexandre Mebazaa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Critically ill Septic shock business.industry Mortality rate Hemodynamics bacterial infections and mycoses Critical Care and Intensive Care Medicine medicine.disease Surgery Cardiac dysfunction Sepsis Adrenomedullin High morbidity Internal medicine Poster Presentation medicine Cardiology business |
| Zdroj: | Intensive Care Medicine Experimental |
| ISSN: | 2197-425X |
| DOI: | 10.1186/2197-425x-3-s1-a618 |
| Popis: | Sepsis and septic shock still represent major health issues, with persisting high morbidity and mortality rates in critically ill patients. Cardiac dysfunction[1] occurs frequently during severe sepsis. Adrenomedullin (ADM) has been identified as a key mediator in vascular tone regulation[1]. A newly developed anti-ADM antibody Adrecizumab (ADZ) may improve hemodynamic dysfunction during resuscitated murine, cecal ligation and puncture (CLP)-induced septic shock[2]. |
| Databáze: | OpenAIRE |
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