Synthesis and antiviral evaluation of carbocyclic analogs of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines

Autor:	Y F, Shealy, J D, Clayton, G, Arnett, W M, Shannon
Rok vydání:	1984
Předmět:	Adenosine Magnetic Resonance Spectroscopy Drug Evaluation Preclinical Vaccinia virus Purine Nucleosides Antiviral Agents Mass Spectrometry Mice Structure-Activity Relationship Spectrophotometry Drug Discovery Animals Simplexvirus Molecular Medicine Indicators and Reagents Leukemia L1210
Zdroj:	Journal of Medicinal Chemistry. 27:670-674
ISSN:	1520-4804 0022-2623
Popis:	Carbocyclic analogues of ribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8- azapurines were prepared from the 2-amino-6-chloropurine ribofuranoside analogue (2) and the 2-amino-6-chloro-8- azapurine ribofuranoside analogue (9), respectively. Analogues of purine ribofuranosides with the chloro, amino, methylamino, or methylthio group at position 6, the thioguanosine analogue, and the previously reported guanosine analogue were evaluated in vitro against herpes simplex virus, type 1 (HSV-1). 8- Azapurine ribofuranoside analogues with the chloro, amino, or methylthio group at position 6 and the previously reported 8- azaguanosine analogue were also evaluated against HSV-1. The carbocyclic analogue (6) of 2,6-diaminopurine ribofuranoside is highly active against HSV-1 and, also, against vaccinia virus. The 2-amino-6-chloropurine, 2-amino-6-(methylamino)purine, and the 2,6-diamino-8- azapurine derivatives also demonstrated significant activity against HSV-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371d43037e493694b89f75c0a64c4b14 https://doi.org/10.1021/jm00371a020 Zobrazit plný text záznamu