Effect of labetalol on cerebral blood flow, oxygen metabolism and autoregulation in healthy humans
| Autor: | Olaf B. Paulson, Karsten Skovgaard Olsen, L. B. Svendsen, Fin Stolze Larsen |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Mean arterial pressure Hemodynamics Blood Pressure Single-photon emission computed tomography Oxygen Consumption Infusion Procedure medicine Homeostasis Humans Labetalol Autoregulation Antihypertensive Agents Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Brain Anesthesiology and Pain Medicine Blood pressure nervous system Cerebral blood flow Cerebrovascular Circulation Anesthesia cardiovascular system Female business circulatory and respiratory physiology medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 75:51-54 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/75.1.51 |
| Popis: | We have studied the effects of labetalol on cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) in eight healthy volunteers. CBF was measured by single photon emission computerized tomography before and during infusion of labetalol. CMRO2 was calculated as CBF x cerebral arteriovenous oxygen content difference (CaO2-CvO2). CBF autoregulation was tested during infusion of labetalol by changing arterial pressure and estimating relative changes in global CBF from changes in (CaO2-CvO2). CBF before and during infusion of labetalol was 67 and 65 ml/100 g min-1, respectively (P > 0.05). CMRO2 was 2.9 and 2.8 ml/100 g min-1, respectively (P > 0.05). CBF autoregulation was preserved in all subjects. The lower limit of CBF autoregulation was 88 mm Hg (94% of baseline mean arterial pressure). We conclude that labetalol did not influence global or regional CBF, or CMRO2, and CBF autoregulation was preserved. |
| Databáze: | OpenAIRE |
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