The role of circulating fibrocytes in inflammation and autoimmunity

Autor:	Carole L. Galligan, Eleanor N. Fish
Rok vydání:	2013
Předmět:	Inflammation business.industry medicine.medical_treatment Immunology Mesenchymal stem cell Autoimmunity Bone Marrow Cells Cell Biology medicine.disease_cause Immune system Cytokine Fibrocyte Chemokine secretion medicine Humans Immunology and Allergy medicine.symptom business Wound healing
Zdroj:	Journal of Leukocyte Biology. 93:45-50
ISSN:	1938-3673 0741-5400
DOI:	10.1189/jlb.0712365
Popis:	Review on the role of circulating fibrocytes in augmenting the inflammatory/immune processes, and contributing to tissue remodeling in autoimmune diseases. Autoimmunity is a chronic process resulting in inflammation, tissue damage, and subsequent tissue remodeling. Circulating fibrocytes are bone marrow-derived cells with characteristics of hematopoietic and mesenchymal cells. These cells have been implicated in many inflammatory and fibrotic conditions as well as in wound healing. Fibrocytes can amplify the inflammatory/immune response through multiple mechanisms, including antigen presentation, cytokine and chemokine secretion, and production of MMPs. Increased numbers of circulating fibrocytes are observed in RA, systemic scleroderma, and Gravesˈ disease. Here, we review the current literature and potential involvement of fibrocytes in inflammation and autoimmunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370c065dec3b4970df6174d4c6c3f36a https://doi.org/10.1189/jlb.0712365 Zobrazit plný text záznamu Plný text