SYNTHESIS AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY RESTRICTED AND NUCLEOBASE-MODIFIED ANALOGS OF THE ANTICANCER COMPOUND 3′-C-ETHYNYLCYTIDINE (ECYD)
| Autor: | Jan Stenvang Jepsen, Patrick J. Hrdlicka, Jesper Wengel |
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| Rok vydání: | 2005 |
| Předmět: |
Antimetabolites
Stereochemistry Chemistry Pharmaceutical Antineoplastic Agents Cytidine Biochemistry Nucleobase Inhibitory Concentration 50 Cell Line Tumor Neoplasms Genetics Ic50 values Humans Uracil Uridine Biological evaluation Chemistry Uracil analog General Medicine Combinatorial chemistry Models Chemical Drug Design Nucleic Acid Conformation Molecular Medicine Drug Screening Assays Antitumor 3'-C-ethynylcytidine |
| Zdroj: | Hrdlicka, P J, Jepsen, J S & Wengel, J 2005, ' Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECYD) ', Nucleosides, Nucleotides and Nucleic Acids, vol. 24, no. 5-7, pp. 397-400 . https://doi.org/10.1081/NCN-200059821 |
| ISSN: | 1532-2335 1525-7770 |
| Popis: | A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3′-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of, the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0.73 μM. |
| Databáze: | OpenAIRE |
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