Biological effects of carbon ion beams with various LETs on budding yeast Saccharomyces cerevisiae
| Autor: | Kikuo Shimizu, Youichirou Matuo, Yoshiya Furusawa, Yoshinobu Izumi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell Survival Health Toxicology and Mutagenesis Saccharomyces cerevisiae Linear energy transfer chemistry.chemical_element Heavy Ion Radiotherapy Biology Microbiology Ion 03 medical and health sciences 0302 clinical medicine Mutation Rate Genetics Heavy Ions Linear Energy Transfer Irradiation Mutation frequency Molecular Biology Dose-Response Relationship Radiation biology.organism_classification Carbon Yeast 030104 developmental biology chemistry Mutagenesis 030220 oncology & carcinogenesis Biophysics |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 810:45-51 |
| ISSN: | 0027-5107 |
| Popis: | It has been established that irradiation with higher linear energy transfer (LET) increases lethality and mutagenicity more than that with lower LET. However, the characteristics specific to carbon ion beam have not yet been elucidated. Yeast cells were irradiated with carbon ions with an LET of 13 or 50keV/μm, and cell survival and mutation frequency were analyzed. The results, combined with our previous findings for ions with an LET of 107keV/μm, demonstrated that, in conjunction with an increase in LET, cell survival decreased, while mutation frequency increased. This indicates that a carbon ion beam with a higher LET is more mutagenic than one with a lower LET. |
| Databáze: | OpenAIRE |
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