Combined treatment of acute EAE in Lewis rats with TNF-binding protein and interleukin-1 receptor antagonist

Autor: L. Munyakazi, Qiao Yan, B. Wiemann, C. Matheson, Gwyneth Van, S. Ogenstad, Dimitry M. Danilenko, C.O. Starnes
Rok vydání: 1998
Předmět:
Integrins
Encephalomyelitis
Autoimmune
Experimental
Encephalomyelitis
medicine.medical_treatment
Injections
Subcutaneous
Sialoglycoproteins
Receptors
Lymphocyte Homing
Integrin alpha4beta1
Drug Administration Schedule
Receptors
Tumor Necrosis Factor
Proinflammatory cytokine
Polyethylene Glycols
Developmental Neuroscience
Receptors
Very Late Antigen
medicine
Animals
Humans
Autoimmune disease
business.industry
Tumor Necrosis Factor-alpha
Experimental autoimmune encephalomyelitis
Interleukin
Brain
medicine.disease
Intercellular Adhesion Molecule-1
Lymphocyte Function-Associated Antigen-1
Rats
Interleukin 1 Receptor Antagonist Protein
Interleukin 1 receptor antagonist
Cytokine
Neurology
Spinal Cord
Rats
Inbred Lew
Immunology
Injections
Intravenous
Tumor necrosis factor alpha
Drug Therapy
Combination
Female
business
Dimerization
Interleukin-1
Zdroj: Experimental neurology. 149(2)
ISSN: 0014-4886
Popis: Experimental autoimmune encephalomyelitis (EAE) is a term given to describe a collection of animal models representing the human disease multiple sclerosis (MS). Although not fully understood, the involvement of cytokines and the immune system in either EAE or human MS is well established. Past efforts have shown that inhibition of proinflammatory cytokines tumor necrosis factor (TNF-alpha) or interleukin-1 (IL-1) result in amelioration of acute EAE in Lewis rats. The present study examined this model for the effect of concomitant inhibition of both TNF-alpha and IL-1, which resulted in a modest but significant therapeutic effect that was superior to inhibition of either single agent alone with respect to four of the five variables used to follow the progression of disease in this model, i.e., clinical severity, frequency of disease, loss of body weight, and day of onset. These results are in accordance with the idea that combination treatments are likely to prove superior to single agent therapy in the treatment of autoimmune inflammatory disease.
Databáze: OpenAIRE
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