Temporal Trends in the Quality of Deceased Donor Kidneys and Kidney Transplant Outcomes in Europe:an analysis by the ERA-EDTA Registry

Autor: Stefan P Berger, Maria Pippias, Jadranka Buturović Ponikvar, Hessel Peters-Sengers, Miha Arnol, Ziad A. Massy, Reinhard Kramar, Ángela Magaz, Anna Varberg Reisæter, Kitty J Jager, Maurizio Nordio, Vianda S. Stel, Søren Schwartz Sørensen, Frederike J. Bemelman
Přispěvatelé: Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, Nephrology, Center of Experimental and Molecular Medicine, Epidemiology and Data Science, ACS - Pulmonary hypertension & thrombosis, APH - Global Health
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pippias, M, Stel, V S, Arnol, M, Bemelman, F, Berger, S P, Buturovic Ponikvar, J B, Kramar, R, Magaz, Á, Nordio, M, Peters-Sengers, H, Reisæter, A V, Sørensen, S S, Massy, Z A & Jager, K J 2022, ' Temporal Trends in the Quality of Deceased Donor Kidneys and Kidney Transplant Outcomes in Europe : an analysis by the ERA-EDTA Registry ', Nephrology Dialysis Transplantation, vol. 37, no. 1, gfab156, pp. 175-186 . https://doi.org/10.1093/ndt/gfab156
Nephrology Dialysis Transplantation
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, 37(1), 175-186. Oxford University Press
Nephrology, dialysis, transplantation, 37(1), 175-186. Oxford University Press
Pippias, M, Stel, V S, Arnol, M, Bemelman, F, Berger, S P, Buturovic Ponikvar, J B, Kramar, R, Magaz, Á, Nordio, M, Peters-Sengers, H, Reisæter, A V, Sørensen, S S, Massy, Z A & Jager, K J 2022, ' Temporal trends in the quality of deceased donor kidneys and kidney transplant outcomes in Europe : An analysis by the ERA-EDTA Registry ', Nephrology Dialysis Transplantation, vol. 37, no. 1, pp. 175-186 . https://doi.org/10.1093/ndt/gfab156
ISSN: 0931-0509
Popis: Background We investigated 10-year trends in deceased donor kidney quality expressed as the kidney donor risk index (KDRI) and subsequent effects on survival outcomes in a European transplant population. Methods Time trends in the crude and standardized KDRI between 2005 and 2015 by recipient age, sex, diabetic status and country were examined in 24 177 adult kidney transplant recipients in seven European countries. We determined 5-year patient and graft survival probabilities and the risk of death and graft loss by transplant cohort (Cohort 1: 2005–06, Cohort 2: 2007–08, Cohort 3: 2009–10) and KDRI quintile. Results The median crude KDRI increased by 1.3% annually, from 1.31 [interquartile range (IQR) 1.08–1.63] in 2005 to 1.47 (IQR 1.16–1.90) in 2015. This increase, i.e. lower kidney quality, was driven predominantly by increases in donor age, hypertension and donation after circulatory death. With time, the gap between the median standardized KDRI in the youngest (18–44 years) and oldest (>65 years) recipients widened. There was no difference in the median standardized KDRI by recipient sex. The median standardized KDRI was highest in Austria, the Netherlands and the Basque Country (Spain). Within each transplant cohort, the 5-year patient and graft survival probability were higher for the lowest KDRIs. There was no difference in the patient and graft survival outcomes across transplant cohorts, however, over time the survival probabilities for the highest KDRIs improved. Conclusions The overall quality of deceased donor kidneys transplanted between 2005 and 2015 has decreased and varies between age groups and countries. Overall patient and graft outcomes remain unchanged.
Databáze: OpenAIRE
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