| Autor: |
Kaoru Imai, Makoto Tanaka, Seiji Miyoshi, Ren Murakami, Akifumi Hagi, Sachi Yamagawa, Daisuke Sano |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
American Journal of Infection Control. 50:764-771 |
| ISSN: |
0196-6553 |
| DOI: |
10.1016/j.ajic.2021.11.020 |
| Popis: |
The purpose of this study was to evaluate the virucidal activity of a new olanexidine-containing formulation for hand hygiene (olanexidine gluconate hand rub; OLG-HR) against non-enveloped viruses and to understand its mechanism of action.The virucidal activities of OLG-HR against two strains of caliciviruses and three adenovirus serotypes were evaluated through suspension tests. Also, virus-like particles were used to predict the effect of olanexidine gluconate on virus particle structure.The results of suspension tests under conditions with and without interfering substances (1.5% BSA) indicated that OLG-HR had a broad-spectrum effect against non-enveloped viruses, and the virucidal effect was unaffected by organic contaminants. Furthermore, olanexidine inhibited the binding ability of virus-like particles to the binding receptor of human norovirus and increased the aggregation of virus-like particles in a dose-dependent manner. Transmission electron microscopy showed that the morphology of the virus-like particles was affected by exposure to olanexidine, indicating that the protein-denaturing effect of olanexidine gluconate caused the loss of receptor-binding capability of the viral capsid protein.This study suggests that olanexidine gluconate is a potential biological and environmental disinfectant against norovirus and adenovirus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect