Composite Biclonal Marginal Zone Lymphoma of Lung and Chronic Lymphocytic Leukemia: Pathologic, Phenotypic, Cytogenetic, and Molecular Study
| Autor: | Vonda Douglas-Nikitin, Samer Ballouz, Mark A. Micale, Sharathkumar Bhagavathi, Kurt Neumann, Ann Marie Blenc |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms Chronic lymphocytic leukemia Biology Immunoglobulin light chain Translocation Genetic Pathology and Forensic Medicine immune system diseases hemic and lymphatic diseases medicine Humans In Situ Hybridization Fluorescence B cell medicine.diagnostic_test MALT lymphoma Lymphoma B-Cell Marginal Zone Gene rearrangement Middle Aged Flow Cytometry medicine.disease Immunohistochemistry Leukemia Lymphoid Lymphoma Leukemia medicine.anatomical_structure Surgery Anatomy Immunoglobulin Heavy Chains Fluorescence in situ hybridization |
| Zdroj: | International Journal of Surgical Pathology. 19:377-381 |
| ISSN: | 1940-2465 1066-8969 |
| Popis: | The simultaneous diagnosis of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare. This study reports a patient with composite synchronous biclonal occurrence of MALT lymphoma of the lung and CLL/SLL. The morphology of the lung and peripheral blood showed features of MALT lymphoma and CLL, respectively. The cytogenetic evaluation of the lung specimen revealed a t(1;14) (p22;q32), a frequent genetic abnormality in MALT lymphoma. Flow cytometry analysis of the lung tissue showed features of MALT lymphoma and CLL/SLL with different light chain restriction, whereas the blood showed phenotypic evidence of CLL/SLL. Fluorescence in situ hybridization study of the blood showed a deletion of 13q14 and 17p13. Immunoglobulin heavy chain (IgH) gene rearrangement study of the lung tissue and blood showed a monoclonal IgH gene rearrangement with distinct light chain restriction, suggesting that the immunophenotypically different cell populations originated from separate clones. |
| Databáze: | OpenAIRE |
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