Computed tomography-guided biopsy of small lung nodules: diagnostic accuracy and analysis for true negatives
| Autor: | Wei-Xin Yang, Wei Li, Xing-Li Liu, Liang Lv, Mao-Ping Rui, Li-Peng Yang, Zhi Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Image-Guided Biopsy
Male Core needle chronic inflammation medicine.medical_specialty Medicine (General) Lung Neoplasms transthoracic core needle biopsy Diagnostic accuracy Computed tomography Computed tomography guided biopsy Sensitivity and Specificity Biochemistry 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine R5-920 Antigens Neoplasm Biopsy medicine Humans Lung Aged Retrospective Studies Keratin-19 medicine.diagnostic_test business.industry fibroplasia Biochemistry (medical) Solitary Pulmonary Nodule Cell Biology General Medicine Middle Aged medicine.anatomical_structure True negative true negative 030220 oncology & carcinogenesis Female small lung nodule diagnostic accuracy Radiology Tomography X-Ray Computed business Retrospective Clinical Research Report |
| Zdroj: | Journal of International Medical Research, Vol 48 (2020) The Journal of International Medical Research |
| ISSN: | 1473-2300 |
| Popis: | Objective We evaluated the diagnostic accuracy of computed tomography (CT)-guided transthoracic core needle biopsy (TCNB) for small (≤20-mm) lung nodules and identified predictive factors for true negatives among benign biopsy results. Methods From March 2010 to June 2015, 222 patients with small lung nodules underwent CT-guided TCNB. We retrospectively analysed data regarding technical success, diagnostic accuracy, and predictors of true negatives. Results The technical success rate was 100%. The TCNB results of the 222 lung nodules included malignancy (n = 136), suspected malignancy (n = 8), specific benign lesion (n = 17), and nonspecific benign lesion (n = 61). The final diagnosis of 222 lung nodules included malignant (n = 160), benign (n = 60), and nondiagnostic lesions (n = 2). The sensitivity, specificity, and overall diagnostic accuracy of CT-guided TCNB for small lung nodules were 90.0%, 100%, and 92.7%, respectively. Pneumothorax and haemoptysis occurred in 23 and 41 patients, respectively. Based on the Cox regression analysis, the significant independent predictive factor for true negatives was a biopsy result of chronic inflammation with fibroplasia. Conclusions CT-guided TCNB offers high diagnostic accuracy for small lung nodules, and a biopsy result of chronic inflammation with fibroplasia can predict a true-negative result. |
| Databáze: | OpenAIRE |
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