Reward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity

Autor: Volodymyr B. Bogdanov, Helen Beyer, Giuseppe Pagnoni, Bruno Aouizerate, Guillaume Ferreira, Lucile Capuron, Bixente Dilharreguy, Sandra Dexpert, Jennifer C. Felger, Ines Delgado, Cédric Beau, Patrick Ledaguenel, Damien Forestier, Olena V. Bogdanova, Eric Magne, Sophie Layé, Agnès Aubert
Přispěvatelé: Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École Nationale des Travaux Publics de l'État (ENTPE), École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement, Brain Dynamics and Cognition Team (U1028 Inserm - UMR5292 CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Service de Chirurgie Digestive et Pariétale, Clinique Tivoli Ducos [Bordeaux], Emory University School of Medicine, Emory University [Atlanta, GA], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Brain Dynamics and Cognition (DYCOG), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), CCSD, Accord Elsevier
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Endocrinology
Diabetes and Metabolism
[SDV]Life Sciences [q-bio]
Precuneus
0302 clinical medicine
Endocrinology
Ghrelin/blood
Prefrontal cortex
media_common
Visual Cortex
2. Zero hunger
Brain Mapping
digestive
oral
and skin physiology
fMRI
Santé humaine
Middle Aged
Magnetic Resonance Imaging
Ghrelin
Obesity
Morbid
[SDV] Life Sciences [q-bio]
Behavior analysis
Psychiatry and Mental health
medicine.anatomical_structure
Cerveau Humain
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Female
psychological phenomena and processes
Rewards
Adult
medicine.medical_specialty
media_common.quotation_subject
Ventromedial prefrontal cortex
Prefrontal Cortex
Gyrus Cinguli
03 medical and health sciences
Reward
Internal medicine
medicine
Humans
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Obesity
Biological Psychiatry
Behavior
Endocrine and Autonomic Systems
business.industry
Ventral striatum
Appetite
Obesité
Obesity/pathology/surgery
030227 psychiatry
Dorsolateral prefrontal cortex
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Posterior cingulate
Ventral Striatum
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
030217 neurology & neurosurgery
Psychomotor Performance
Zdroj: Psychoneuroendocrinology
Psychoneuroendocrinology, Elsevier, 2020, 112, pp.1-8. ⟨10.1016/j.psyneuen.2019.104520⟩
Psychoneuroendocrinology, 2020, 112, pp.1-8. ⟨10.1016/j.psyneuen.2019.104520⟩
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2019.104520⟩
Popis: International audience; Background/objectives: While excessive food consumption represents a key factor in the development of obesity, the underlying mechanisms are still unclear. Ghrelin, a gut-brain hormone involved in the regulation of appetite, is impaired in obesity. In addition to its role in eating behavior, this hormone was shown to affect brain regions controlling reward, including the striatum and prefrontal cortex, and there is strong evidence of impaired reward processing in obesity. The present study investigated the possibility that disrupted reward-related brain activity in obesity relates to ghrelin deficiency.Subjects/methods: Fifteen severely obese subjects (BMI > 35 kg/m(2)) and fifteen healthy non-obese control subjects (BMI < 30 kg/m(2)) were recruited. A guessing-task paradigm, previously shown to activate the ventral striatum, was used to assess reward-related brain neural activity by functional magnetic resonance imaging (fMRI). Fasting blood samples were collected for the measurement of circulating ghrelin.Results: Significant activations in the ventral striatum, ventromedial prefrontal cortex and extrastriate visual cortex were elicited by the fMRI task in both obese and control subjects. In addition, greater reward-related activations were present in the dorsolateral prefrontal cortex, and precuneus/posterior cingulate of obese subjects compared to controls. Obese subjects exhibited longer choice times after repeated reward and lower circulating ghrelin levels than lean controls. Reduced ghrelin levels significantly predicted slower post-reward choices and reward-related hyperactivity in dorsolateral prefrontal cortices in obese subjects.Conclusion: This study provides evidence of association between circulating ghrelin and reward-related brain activity in obesity and encourages further exploration of the role of ghrelin system in altered eating behavior in obesity.
Databáze: OpenAIRE
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