Blockade of intra-articular TNF in peripheral spondyloarthritis: Its relevance to clinical scores, quantitative imaging and synovial fluid and synovial tissue biomarkers
| Autor: | Elena Scagliori, Antonio Di Maggio, R. Nardacchione, Pascale Roux-Lombard, Leopoldo Rubaltelli, Katia Gazzola, Luisa Costa, Fiorella Calabrese, Beatrice Molena, Benedetta Accordi, Francesca Oliviero, L Cozzi, Ugo Fiocco, Francesca Lunardi, Roberto Stramare, Leonardo Punzi, Jean-Michel Dayer, Mara Felicetti, Paolo Sfriso |
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| Přispěvatelé: | Ugo, Fiocco, Paolo, Sfriso, Francesca, Oliviero, Francesca, Lunardi, Fiorella, Calabrese, Elena, Scagliori, Luisella, Cozzi, Antonio Di, Maggio, Roberto, Nardacchione, B?atrice, Molena, Mara, Felicetti, Katia, Gazzola, Roberto, Stramare, L?opoldo, Rubaltelli, Benedetta, Accordi, Costa, Luisa, Pascale Roux, Lombard, Leonardo, Punzi, Jean Michel, Dayer |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male musculoskeletal diseases Pathology medicine.medical_specialty Interleukin-1beta Knee Joint Peripheral blood mononuclear cell Severity of Illness Index Receptors Tumor Necrosis Factor Etanercept Injections Intra-Articular Rheumatology Synovitis Spondylarthritis Synovial Fluid medicine Synovial fluid Humans ddc:616 medicine.diagnostic_test business.industry Interleukin-6 Tumor Necrosis Factor-alpha Synovial Membrane Magnetic resonance imaging medicine.disease Interleukin 1 Receptor Antagonist Protein medicine.anatomical_structure Treatment Outcome Antirheumatic Agents Immunoglobulin G Tumor necrosis factor alpha Female Synovial membrane business Biomarkers medicine.drug |
| Zdroj: | Joint, Bone, Spine, Vol. 80, No 2 (2013) pp. 165-170 |
| ISSN: | 1297-319X |
| Popis: | Objectives This open-label study is based on a translational approach with the aim of detecting changes in the clinical condition as well as in imaging and synovial biological markers in both synovial fluid (SF) and synovial tissue (ST) in peripheral spondyloarthritis (SpA) patients following intra-articular (IA) blockade of TNF-α by serial etanercept injections. Methods Twenty-seven SpA patients with resistant knee synovitis underwent four biweekly IA injections of etanercept (E) (12.5 mg). The primary outcome of Thompson's Knee Index (THOMP), and secondary outcomes of Knee Joint Articular Index (KJAI), C-reactive protein (CRP), HAQ-Disability Index (HAQ-DI), maximal synovial thickness (MST) according to ultrasonography (US) and contrast-enhanced magnetic resonance (C+MR) imaging, ST-CD45+ mononuclear cells (MNC) and ST-CD31+ vessels, IL-1β, IL-1Ra and IL-6 levels in SF were assessed at baseline and at the end of the study. Results At the study end, clinical and imaging outcomes as well as ST and SF biological markers were significantly reduced compared to baseline. There were significant correlations between clinical, imaging and biological markers (CRP with either THOMP, or KJAI, or HAQ-DI or SF-IL-1Ra; US-MST with KJAI, ST-CD45+ with either THOMP, or KJAI, or ST-CD31+, or SF-IL-1β; SF-IL-6 with either THOMP, or KJAI, or SF-IL-1β, or IL-1Ra). Conclusions The proof of concept study revealed early improvement either in local and systemic clinical scores, in synovial thickness measures by C+MR and US, or expression of synovial biological markers. CD45+, CD31+ in ST and IL-6 and IL-1β in SF may be considered potential biomarkers of the peripheral SpA response to IA TNF-α blocking. |
| Databáze: | OpenAIRE |
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