| Popis: |
Additional file 3. Compilation of multiple supplementary figures (S1–S7). Fig. S1 is a two-color heatmap showing the relationship between WGCNA modules and the bicor correlation of age. Fig. S2 contains multiple Box plots of WGCNA modules (M1, M2, M4, M8, M9, M10, M11, M12, M13, M14, M15, M17, M18, M20, M21, M22, M23, M24, M25, and M26). Fig. S3 displays Igraphs of modules (M3, M5, M6, M7, M16, and M19) that are associated with knockout (Grn−/−) status and corresponding gene symbols as nodes. Fig. S4 displays Igraphs of modules (M1, M2, M4, M8, M9, M10, M11, M12, M13, M14, M15, M17, M18, M20, M21, M22, M23, M24, M25, and M26 modules) associated with knockout (Grn−/−) status and corresponding gene symbols as nodes. Fig. S5 summarizes the gene ontology (GO) enrichment analysis of proteins in M1, M2, M4, M8, M9, M10, M11, M12, M13, M14, M15, M17, M18, M20, M21, M22, M23, M24, M25, and M26 modules. Light-green bars: biological process, light-blue bars: molecular function, brown-bars: cellular component. Fig. S6 is an immunoadsorption validation experiment demonstrating an anti-human GPNMB antibody binds antigen specifically on human brain sections. Fig. S7 GPNMB immunostaining was performed on frontal lobe tissue sections from four FTD-GRN patients. |
