Metabolic inflexibility in youth with obesity: Is it a feature of obesity or distinctive of youth who are metabolically unhealthy?
| Autor: | SoJung Lee, Silva A. Arslanian, Nour Gebara, Joon Young Kim, Fida Bacha |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Metabolic Syndrome
Obesity Metabolically Benign medicine.medical_specialty Adolescent business.industry Endocrinology Diabetes and Metabolism Adipose tissue Insulin sensitivity medicine.disease Obesity Article Respiratory quotient Endocrinology Adipose Tissue Normal weight Internal medicine Cohort Metabolically healthy obesity medicine Humans Insulin Lipolysis Insulin Resistance business |
| Zdroj: | Clin Obes |
| ISSN: | 1758-8111 1758-8103 |
| DOI: | 10.1111/cob.12501 |
| Popis: | BACKGROUND: Individuals with obesity have metabolic inflexibility with diminished fasting fat oxidation and blunted increase in respiratory quotient (RQ) in insulin-stimulated states. However, it is unclear if metabolic inflexibility is a characteristic of obesity per se or is unique to youth who have metabolically unhealthy obesity (MUO) compared with metabolically healthy obesity (MHO). OBJECTIVE: We investigated metabolic flexibility in youth with MUO, MHO and normal weight (NW) and compared their metabolic characteristics. PATIENTS/DESIGN: Youth (n=188) were divided, based on cut-off points for in vivo insulin sensitivity (IS) of adolescents with NW, into 137 with MUO and 51 with MHO. Fasting hepatic IS (HIS) from hepatic glucose production by [6,6-(2)H(2)]glucose, adipose tissue IS (ATIS) from whole-body lipolysis by [(2)H(5)]glycerol, RQ (indirect calorimetry) during fasting and a hyperinsulinemic (80mu/m(2)/min)-euglycemic clamp were measured. RESULTS: Youth with MUO vs. MHO had blunted ΔRQ (p=0.035) and lower HIS and ATIS (both p |
| Databáze: | OpenAIRE |
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