Predicting Response to Pregabalin from Pretreatment Pain Quality: Clinical Applications of the Pain Quality Assessment Scale
| Autor: | Mark P. Jensen, Bradley S. Galer, Achilles Alon, Arnold R. Gammaitoni, David J. Hewitt, James Bolognese, Steven S. Smugar |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Diabetic neuropathy Pregabalin Logistic regression Predictive Value of Tests Pain assessment Post-hoc analysis Ethnicity medicine Humans gamma-Aminobutyric Acid Aged Pain Measurement Aged 80 and over Analgesics business.industry Peripheral Nervous System Diseases General Medicine Middle Aged medicine.disease Treatment Outcome Anesthesiology and Pain Medicine Predictive value of tests Neuropathic pain Neuralgia Physical therapy Female Neurology (clinical) business Algorithms medicine.drug |
| Zdroj: | Pain Medicine. 14:526-532 |
| ISSN: | 1526-4637 1526-2375 |
| DOI: | 10.1111/j.1526-4637.2012.01423.x |
| Popis: | Objective. The aim of this study is to assess the Pain Quality Assessment Scale (PQAS) in predicting pregabalin in peripheral neuropathic pain (NP). Study Design. Post hoc analysis of a double-blind, placebo-controlled, enriched enrollment, randomized withdrawal trial evaluating pregabalin in 99 patients with NP who completed the PQAS, which comprises 20 questions regarding individual pain domains and qualities that are scored into three scales: paroxysmal, deep, and surface. Methods. Patients rated the average pain intensity and pain quality using the PQAS at baseline; average pain intensity was assessed again after 40 days of treatment with pregabalin. Associations between pretreatment PQAS scores and treatment response were estimated using Pearson's r. Logistic regression was used to identify pretitration PQAS scores contributing unique variance to predicting treatment response. Results. Fifty participants provided baseline PQAS scores and received pregabalin for the entire length of the study. Nine of 23 PQAS baseline scales and items were significantly associated with treatment response to pregabalin: the paroxysmal and deep scales, and the items assessing the following pain domains and qualities: intensity, electric, tingling, cramping, radiating, throbbing, and deep (P values range, 0.002–0.045; rs range, 0.28–0.43). The PQAS items assessing sharp, hot, and unpleasant pain items demonstrated nonsignificant trends (P |
| Databáze: | OpenAIRE |
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