The human T‐cell receptor repertoire in health and disease and potential for omics integration
| Autor: | John J. Miles, Thomas S Watkins |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Sequencing data Receptors Antigen T-Cell chemical and pharmacologic phenomena Disease Computational biology Biology DNA sequencing 03 medical and health sciences 0302 clinical medicine Neoplasms Animals Humans Immunology and Allergy Immunodiagnostics T-cell receptor Computational Biology High-Throughput Nucleotide Sequencing hemic and immune systems Cell Biology Omics T-Cell Receptor Repertoire 030104 developmental biology Fish 030215 immunology |
| Zdroj: | Immunology & Cell Biology. 99:135-145 |
| ISSN: | 1440-1711 0818-9641 |
| DOI: | 10.1111/imcb.12377 |
| Popis: | The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cancers that look to consume our resources. This review describes the genetics and architecture of the human TCR and highlights surprising new discoveries over the past years that have disproved very old dogmas. The standardization of TCR sequencing data is discussed in preparation for big data bioinformatics and predictive analysis. We next catalogue new signatures and phenomenon discovered by TCR next generation sequencing (NGS) in health and disease and work that remain to be done in this space. Finally, we discuss how TCR NGS can add to immunodiagnostics and integrate with other omics platforms for both a deeper understanding of TCR biology and its use in the clinical setting. |
| Databáze: | OpenAIRE |
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