Intra-erythrocyte chromium as an indicator of exposure to hexavalent chromium: An in vivo evaluation in intravenous administered rat
| Autor: | Elodie Bonfanti, Samuel Muller, Sylvie Michaux, Hervé Nunge, Jérôme Devoy, Stéphane Viton, Mylène Lorcin, Frédéric Cosnier, Sylvie Sébillaud, Marie-Josèphe Décret, Carole Seidel, Laurine Douteau, Guillaume Antoine, Anne-Marie Lambert-Xolin, Stéphane Grossmann, Laurent Gaté |
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| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
Chromium Male Erythrocytes Urinary system chemistry.chemical_element Urine 010501 environmental sciences Toxicology 01 natural sciences Models Biological Excretion Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Species Specificity In vivo otorhinolaryngologic diseases Animals Hexavalent chromium Carcinogen 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Radiochemistry technology industry and agriculture Reproducibility of Results General Medicine Ammonium dichromate Carcinogens Environmental 3. Good health Toxicokinetics chemistry Body Burden Administration Intravenous Oxidation-Reduction Biomarkers |
| Zdroj: | Toxicology letters. 314 |
| ISSN: | 1879-3169 |
| Popis: | Hexavalent chromium (Cr(VI)) compounds are classified as carcinogenic to humans. Whereas chromium measurements in urine and plasma attest to the last few hours of total chromium exposure (all oxidation states of chromium), chromium in red blood cells (RBC) is attributable specifically to Cr(VI) exposure over the last few days. Before recommending Cr in RBC (CrIE) as a biological indicator of Cr(VI) exposure, in vivo studies must be undertaken to assess its reliability. The present study examines the kinetics of Cr(VI) in rat after a single intravenous dose of ammonium dichromate. Chromium levels were measured in plasma, red blood cells and urine. The decay of the chromium concentration in plasma is one-phase-like (with half-life time of 0.55 day) but still measurable two days post injection. The excretion of urinary chromium peaks between five and six hours after injection and shows large variations. Intra-erythrocyte chromium (CrIE) was very constant up to a minimum of 2 days and half-life time was estimated to 13.3 days. Finally, Cr(III) does not interfere with Cr(VI) incorporation in RBC. On the basis of our results, we conclude that, unlike urinary chromium, chromium levels in RBC are indicative of the amount of dichromate (Cr(VI)) in blood. |
| Databáze: | OpenAIRE |
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