Molecular Weight and Charge Density Effects of Guanidinylated Biodegradable Polycarbonates on Antimicrobial Activity and Selectivity
| Autor: | Ralph P. Cooney, Margaret A. Brimble, Chao Liang, Jianyong Jin, Chloe A Hae Cho, Vijayalekshmi Sarojini, Kyriakos G. Varnava, Jie Liu, Duncan J. McGillivray, Simon Swift, Janesha Perera |
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| Rok vydání: | 2017 |
| Předmět: |
Erythrocytes
Polymers and Plastics Staphylococcus Static Electricity Alkyne Bioengineering Biodegradable Plastics 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials chemistry.chemical_compound Anti-Infective Agents Candida albicans Materials Chemistry Animals Organic chemistry Polycarbonate Guanidine chemistry.chemical_classification Sheep Molecular mass Cationic polymerization 021001 nanoscience & nanotechnology Antimicrobial 0104 chemical sciences Molecular Weight chemistry visual_art Pseudomonas aeruginosa Click chemistry visual_art.visual_art_medium Click Chemistry 0210 nano-technology Selectivity |
| Zdroj: | Biomacromolecules. 19:1389-1401 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.7b01245 |
| Popis: | Six guanidine functionalized aliphatic biodegradable polycarbonates with varying molecular weights and charge densities were synthesized via postsynthesis modification of alkyne containing polycarbonates using Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The concept of passive diluting group was to modify the cationic charge density of the polycarbonate without changing its hydrophilicity. Within the molecular weight range from 8000 to 30000 g mol–1, these guanidine polycarbonates exhibited broad-spectrum biocidal activity with low toxicity to red blood cells (RBCs). The lowest molecular weight homopolymer sample (PG-8k-100) showed the best antimicrobial activity (MIC = 40 μg/mL against Escherichia coli and MIC = 20 μg/mL against Staphylococcus epidermidis) and least RBC toxicity (0.6% hemolysis at MIC). Within the three guanidine charge densities from 20% to 70%, the low to medium dilution samples (PG-8k-7030 and PG-8k-5050) had no obvious loss in antimicrobial activities compared ... |
| Databáze: | OpenAIRE |
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