Matriptase-Induced Phosphorylation of MET is Significantly Associated with Poor Prognosis in Invasive Bladder Cancer; an Immunohistochemical Analysis

Autor: Masato Fujii, Kozue Nakahara, Toshiyuki Kamoto, Yoshinobu Toda, Akinobu Ohno, Koji Yamasaki, Naoki Terada, Yuichiro Sato, Hiroaki Kataoka, Shoichiro Mukai, Takahiro Nagai
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
matriptase
Proto-Oncogene Mas
Catalysis
Article
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
medicine
Biomarkers
Tumor
Humans
Matriptase
Physical and Theoretical Chemistry
Phosphorylation
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Aged
Bladder cancer
biology
Activator (genetics)
business.industry
Organic Chemistry
Serine Endopeptidases
Cancer
General Medicine
Proto-Oncogene Proteins c-met
medicine.disease
Computer Science Applications
030104 developmental biology
hepatocyte growth factor
Urinary Bladder Neoplasms
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
biology.protein
Cancer research
MET
Immunohistochemistry
bladder cancer
Hepatocyte growth factor
Female
business
Protein Processing
Post-Translational
medicine.drug
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 12, p 3708 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Hepatocyte growth factor (HGF) plays an important role in cancer progression via phosphorylation of MET (c-met proto-oncogene product, receptor of HGF). HGF-zymogen (pro-HGF) must be processed for activation by HGF activators including matriptase, which is a type II transmembrane serine protease and the most efficient activator. The enzymatic activity is tightly regulated by HGF activator inhibitors (HAIs). Dysregulated pro-HGF activation (with upregulated MET phosphorylation) is reported to promote cancer progression in various cancers. We retrospectively analyzed the expression of matriptase, phosphorylated-MET (phospho-MET) and HAI-1 in tumor specimens obtained from patients with invasive bladder cancer by immunohistochemistry. High expression of phospho-MET and increased expression of matriptase were significantly associated with poor prognosis, and high matriptase/low HAI-1 expression showed poorer prognosis. Furthermore, high expression of matriptase tended to correlate with phosphorylation of MET. Increased expression of matriptase may induce the ligand-dependent activation of MET, which leads to poor prognosis in patients with invasive bladder cancer.
Databáze: OpenAIRE
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