Early post-transplant complications following ABO-incompatible kidney transplantation
| Autor: | Lionel Rostaing, Nicolas Doumerc, Xavier Gamé, Laure Esposito, Asma Allal, Bénédicte Debiol, Hamza Naciri Bennani, Nassim Kamar, Federico Sallusto, Zhyiar Abdulrahman, Antoine Delarche |
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| Rok vydání: | 2015 |
| Předmět: |
Prothrombin time
medicine.medical_specialty Blood transfusion medicine.diagnostic_test business.industry medicine.medical_treatment Surgical complications Bleeding Fibrinogen Retrospective cohort study Bleed medicine.disease Surgery Transplantation Kidney transplantation surgical procedures operative BK virus Nephrology ABO blood group system Cohort medicine Original Article business |
| Zdroj: | Journal of Nephropathology |
| ISSN: | 2251-8363 |
| Popis: | Background: Living-kidney transplantation is increasing because of the scarcity of kidneys from deceased donors and the increasing numbers of patients on waiting lists for a kidney transplant. Living-kidney transplantation is now associated with increased long-term patient- and allograft-survival rates. Objectives: The purpose of this retrospective study was to identify, in a cohort of 44 ABO-incompatible (ABOi) live-kidney transplant patients, the main complications that occurred within 6 months post-transplantation, and to compare these findings with those from 44 matched ABO-compatible (ABOc) live-kidney transplant patients who were also from our center. Patients and Methods: This single-center retrospective study assessed post-transplantation complications in 44 ABO-i versus 44 matched ABO-c patients. All patients were comparable at baseline except that ABO-i patients had greater immunological risks. Results: During the 6-month post-transplant period, more ABO-i patients presented with postoperative bleeds, thus requiring significantly more blood transfusions. Bleeds were associated with significantly lower values of fibrinogen, platelets, prothrombin time, and hemoglobin levels. Surgical complications, patient- and graft-survival rates, and kidney-function statuses were similar between both groups at 6 months post-transplantation. Conclusions: We conclude that impairment of hemostatic factors at pre-transplant explained the increased risk of a post-transplant bleed in ABO-i patients. |
| Databáze: | OpenAIRE |
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