Cytotoxic Bisindole Alkaloids from a Marine Sponge Spongosorites sp
| Autor: | Kwang Sik Im, Xin-Sheng Yao, Jongki Hong, Chong-O. Lee, Baoquan Bao, Qishi Sun, Chung Ja Sim, Jee H. Jung |
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| Rok vydání: | 2005 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Antineoplastic Agents Pharmacognosy Indole Alkaloids Analytical Chemistry Drug Discovery Tumor Cells Cultured Animals Humans Organic chemistry Antibacterial agent Pharmacology Korea Molecular Structure biology Chemistry Alkaloid Organic Chemistry Absolute configuration Biological activity biology.organism_classification Anti-Bacterial Agents Porifera Sponge Complementary and alternative medicine Proton NMR Molecular Medicine Methicillin Resistance Drug Screening Assays Antitumor Antibacterial activity |
| Zdroj: | Journal of Natural Products. 68:711-715 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np049577a |
| Popis: | Three new bisindole alkaloids of the hamacanthin class (1-3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole alkaloids (4, 5, 7-11) from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR, MS, and IR spectroscopic analyses. Configurations of compounds 1-4 were derived from 1H NMR data and optical rotation. Compounds 1, 4, 5, and 11 showed moderate to significant cytotoxicity against five human tumor cell lines, and compounds 1-5 showed weak antibacterial activity against clinically isolated methicillin-resistant strains. |
| Databáze: | OpenAIRE |
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