The role of nitrite ion in phagocyte function—perspectives and puzzles
| Autor: | Jonathan L. Cape, James K. Hurst |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Phagocyte
Phagocytosis Biophysics Oxidative phosphorylation Biology medicine.disease_cause Biochemistry Article chemistry.chemical_compound Phagosomes medicine Animals Humans Nitrite Molecular Biology Nitrites Reactive nitrogen species Phagosome chemistry.chemical_classification Phagocytes Reactive oxygen species Bacteria Macrophages Macrophage Activation Oxidative Stress medicine.anatomical_structure chemistry Cyclooxygenase 2 Cyclooxygenase 1 Leukocytes Mononuclear Endothelium Vascular Oxidative stress |
| Zdroj: | Archives of Biochemistry and Biophysics. 484:190-196 |
| ISSN: | 0003-9861 |
| DOI: | 10.1016/j.abb.2009.01.010 |
| Popis: | Macrophages and neutrophils are essential elements of host cellular defense systems that function, at least in part, by generating respiration-driven oxidative toxins in response to external stimuli. In both cells, encapsulation by phagocytosis provides a mechanism to direct the toxins against the microbes. The toxic chemicals formed by these two phagocytic cells differ markedly, as do the enzymatic catalysts that generate them. Nitrite ion is microbicidal under certain conditions, is generated by activated macrophages, and is present at elevated concentration levels at infection sites. In this review, we consider potential roles that nitrite might play in cellular disinfection by these phagocytes within the context of available experimental information. Although the suggested roles are plausible, based upon the chemical and biochemical reactivity of NO2(-), studies to date provide little support for their implementation within phagosomes. |
| Databáze: | OpenAIRE |
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