Efficacy and Safety of a Single-Pill Fixed-Dose Combination of Azilsartan and Amlodipine
| Autor: | Shin-ichiro Miura, Kota Motozato, Keijiro Saku, Takaaki Kusumoto, Yuhei Shiga |
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| Rok vydání: | 2016 |
| Předmět: |
Amlodipine 5 MG
business.industry Fixed-dose combination General Medicine 030204 cardiovascular system & hematology Pharmacology Blockers 03 medical and health sciences 0302 clinical medicine Irbesartan Blood pressure Valsartan Calcium channel Pill Azilsartan medicine Original Article 030212 general & internal medicine Amlodipine business medicine.drug Angiotensin II type 1 Receptor |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3003 |
| Popis: | Background: Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications. There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at reducing blood pressure (BP). Methods: Forty hypertensive patients who were receiving a single-pill fixed-dose combination of valsartan 80 mg/day and amlodipine 5 mg/day or irbesartan 100 mg/day and amlodipine 5 mg/day were enrolled. They were randomly divided into two treatment groups, a group that changed to a single-pill fixed-dose combination of azilsartan 20 mg/day and amlodipine 5 mg/day (changeover group) and a group that continued to receive valsartan 80 mg/day and amlodipine 5 mg/day or irbesartan 100 mg/day and amlodipine 5 mg/day (control group), and treated for 16 weeks. Results: There were no significant differences in systolic blood pressure (SBP), diastolic blood pressure (DBP) or pulse rate (PR) at 16 weeks between the control and changeover groups. In addition, there were no significant changes in biochemical parameters throughout the study period in both groups. Conclusion: The ability of a single-pill fixed-dose combination of azilsartan and amlodipine to reduce BP may be comparable to that of a combination of valsartan and amlodipine or irbesartan and amlodipine. J Clin Med Res. 2016;8(12):888-892 doi: http://dx.doi.org/10.14740/jocmr2768w |
| Databáze: | OpenAIRE |
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