Screening and Characterization of Hydrate Forms of T-3256336, a Novel Inhibitor of Apoptosis (IAP) Protein Antagonist
| Autor: | Kentaro Hashimoto, Shoko Takeuchi, Yukihiro Ikeda, Tomoyasu Ishikawa, Hiroyuki Sumi, Takashi Kojima, Bunnai Saito |
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| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Water activity Clathrate hydrate Crystallography X-Ray Phase Transition Inhibitor of Apoptosis Proteins law.invention Drug Stability law Desorption Drug Discovery Humans Crystallization Solubility Calorimetry Differential Scanning Chemistry Water Humidity Sorption General Chemistry General Medicine Chemical engineering Pyrazines Anhydrous Hydrate Oligopeptides |
| Zdroj: | CHEMICAL & PHARMACEUTICAL BULLETIN. 63:858-865 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Different crystal packing of hydrates from anhydrate crystals leads to different physical properties, such as solubility and stability. Investigation of the potential of varied hydrate formation, and understanding the stability in an anhydrous/hydrate system, are crucial to prevent an undesired transition during the manufacturing process and storage. Only one anhydrous form of T-3256336, a novel inhibitor of apoptosis (IAP) protein antagonist, was discovered during synthesis, and no hydrate form has been identified. In this study, we conducted hydrate screening such as dynamic water vapor sorption/desorption (DVS), and the slurry experiment, and characterized the solid-state properties of anhydrous/hydrate forms to determine the most desirable crystalline form for development. New hydrate forms, both mono-hydrate and hemi-hydrate forms, were discovered as a result of this hydrate screening. The characterization of two new hydrate forms was conducted, and the anhydrous form was determined to be the most desirable development form of T-3256336 in terms of solid-state stability. In addition, the stability of the anhydrous form was investigated using the water content and temperature controlled slurry experiment to obtain the desirable crystal form in the crystallization process. The water content regions of the stable phase of the desired form, the anhydrous form, were identified for the cooling crystallization process. |
| Databáze: | OpenAIRE |
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