OncotypeDX Recurrence Score Does Not Predict Nodal Burden in Clinically Node Negative Breast Cancer Patients

Autor:	R. F. Hwang, Funda Meric-Bernstam, Sarah M. DeSnyder, K. Park, A. S. Caudle, M. Teshome, C. H. Barcenas, Anthony Lucci, Isabelle Bedrosian, Roland L. Bassett, H. M. Kuerer, D. M. Black, E. Fitzsullivan, Kelly K. Hunt, Sarah E. Tevis, Elizabeth A. Mittendorf, Alastair M. Thompson
Rok vydání:	2018
Předmět:	Oncology Adult medicine.medical_specialty Sentinel lymph node Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Surgical oncology Internal medicine medicine Biomarkers Tumor Humans Genetic Testing Prospective Studies Prospective cohort study Lymph node Aged Retrospective Studies Aged 80 and over business.industry Sentinel Lymph Node Biopsy Gene Expression Profiling Carcinoma Ductal Breast Axillary Lymph Node Dissection Retrospective cohort study Middle Aged medicine.disease Prognosis Dissection medicine.anatomical_structure 030220 oncology & carcinogenesis Lymphatic Metastasis 030211 gastroenterology & hepatology Surgery Female Neoplasm Recurrence Local Sentinel Lymph Node business Follow-Up Studies
Zdroj:	Annals of surgical oncology. 26(3)
ISSN:	1534-4681
Popis:	OncotypeDX recurrence score (RS)® has been found to predict recurrence and disease-free survival in patients with node negative breast cancer. Whether RS is useful in guiding locoregional therapy decisions is unclear. We sought to evaluate the relationship between RS and lymph node burden. Patients with invasive breast cancer who underwent sentinel lymph node dissection from 2010 to 2015 were identified from a prospectively maintained database. Patients were excluded if they were clinically node positive or if they received neoadjuvant chemotherapy. RS was classified as low ( 30). The association between RS, lymph node burden, and disease recurrence was evaluated. Statistical analyses were performed in R version 3.4.0; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362eebb62ef86ca9b172ab598760be54 https://pubmed.ncbi.nlm.nih.gov/30556120 Zobrazit plný text záznamu Full text from SpringerLink