Genomic organization of the interleukin-1 locus
| Autor: | Blair R. Renshaw, John E. Sims, Kirsten E. Garka, Scott L. Taylor, Dirk E. Smith |
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| Rok vydání: | 2002 |
| Předmět: |
DNA
Complementary Sequence analysis Molecular Sequence Data Locus (genetics) Biology Synteny Mice Complementary DNA Gene Order Genetics Gene family Animals Humans Amino Acid Sequence Cloning Molecular Gene Genomic organization Base Sequence Sequence Homology Amino Acid Intron Chromosome Mapping Exons Sequence Analysis DNA Introns Alternative Splicing Genes Chromosomes Human Pair 2 Multigene Family Sequence Alignment Interleukin-1 |
| Zdroj: | Genomics. 79(5) |
| ISSN: | 0888-7543 |
| Popis: | Recent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of these genes. The order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus. There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7. |
| Databáze: | OpenAIRE |
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