Effects of disulfiram on growth, longevity, and reproduction of the albino rat
| Autor: | Paul M. Lish, Marvin H. Malone, W.W. Westerfeld, Harald G.O. Holck, David W. Sjogren |
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| Rok vydání: | 1970 |
| Předmět: |
Male
Xanthine Oxidase media_common.quotation_subject Longevity Pharmaceutical Science Ascorbic Acid Growth Biology Pharmacology chemistry.chemical_compound Oxygen Consumption Sex Factors Disulfiram medicine Animals Xanthine oxidase media_common Molybdenum Reproduction Body Weight Age Factors Ascorbic acid Blood Cell Count Diet Rats Powdered food Oral ingestion chemistry Liver Female Reproductive effects medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 59(9) |
| ISSN: | 0022-3549 |
| Popis: | Chronic oral ingestion of disulfiram at concentrations of 1:1000 and 1:2000 in powdered food retards the growth and reproductive capacity of the albino rat; a concentration of 1:1000 also decreases longevity. Enhancement of diet with ascorbic acid has no antidotal action on the growth and reproductive effects. Chronic disulfiram feeding appears to have no significant effects on whole animal oxygen consumption, blood counts, tissue xanthine oxidase activity, and liver molybdenum content. Calcium deposition in the cerebellum was absent. |
| Databáze: | OpenAIRE |
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