One-year safety and quality of life outcomes in patients with atrial fibrillation on dronedarone: prospective, non-interventional study in German ambulatory care

Autor: R.F. Bosch, B. von Stritzky, G. Benninger, W.D. Paar, David Pittrow, Andreas Goette
Rok vydání: 2015
Předmět:
Male
medicine.medical_treatment
Amiodarone
Cardioversion
Beobachtungsstudie
Quality of life
Germany
Atrial Fibrillation
Ambulatory Care
Prevalence
Langzeitergebnisse
Sinus rhythm
Longitudinal Studies
Prospective Studies
Prospective cohort study
Observational
Dronedarone
Lebensqualität
Aged
80 and over
Atrial fibrillation
Original Contribution
Middle Aged
Sicherheit
Treatment Outcome
Tolerability
Patient Satisfaction
Female
Patient Safety
Safety
Therapie
Cardiology and Cardiovascular Medicine
Anti-Arrhythmia Agents
medicine.drug
Adult
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions
Visual analogue scale
Outcomes
Risk Assessment
Vorhofflimmern
Physiology (medical)
Internal medicine
Long term
medicine
Humans
Aged
business.industry
medicine.disease
Treatment
business
Zdroj: Herzschrittmachertherapie & Elektrophysiologie
ISSN: 1435-1544
0938-7412
DOI: 10.1007/s00399-015-0360-z
Popis: Background and aims The multichannel blocker dronedarone is currently indicated for the maintenance of sinus rhythm after successful cardioversion in adult clinically stable patients with paroxysmal or persistent atrial fibrillation (AF), with careful monitoring of cardiac, hepatic and renal function. We aimed to investigate patients’ quality of life (QoL) and tolerability and effectiveness of dronedarone under real life conditions. Methods In the 1-year prospective, non-interventional IMPULS study, 161 office-based cardiologists, general practitioners and internists throughout Germany documented 549 patients with AF who were currently or newly prescribed dronedarone (safety set, SS). Of those, 342 patients (full analysis set, FAS) provided data on QoL at baseline, 6 months and 12 months). Results Mean age of patients was 67.6/66.3 years; 53.0 %/57.3 % were men (SS/FAS). AF type at inclusion in the SS/FAS was paroxysmal in 71.9 %/71.3 % and persistent in 26.0 %/26.6 % (missing in 2.0 %/2.0 %). The proportion of patients in sinus rhythm increased from 44.6 % at baseline to 70.2 % (SS). The mean value on the 100-point visual analogue scale (EuroQol EQ-5D) increased from 62.3 ± 17.1 at baseline by 11.4 ± 18.7 points (FAS, p
Databáze: OpenAIRE
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