Safety and Pharmacokinetics of Ioversol in Healthy Volunteers
| Autor: | John R. Whittington, Avijit Lahiri, G. Brigden, L. O. Hughes, R.A. Wilkins, M E Heber |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_treatment Contrast Media Blood Pressure Physical examination Electrocardiography Random Allocation Ioversol Iodinated contrast Pharmacokinetics Triiodobenzoic Acids Healthy volunteers medicine Humans Single-Blind Method Radiology Nuclear Medicine and imaging Saline Random allocation medicine.diagnostic_test business.industry General Medicine Blood pressure Anesthesia Drug Evaluation Iodobenzoates Safety business Blood Chemical Analysis medicine.drug |
| Zdroj: | Investigative Radiology. 24:781-788 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/00004424-198910000-00011 |
| Popis: | Ioversol 320, a new nonionic iodinated contrast medium, was injected intravenously into 24 healthy male volunteers using saline as a control. Physical examination, vital signs, electrocardiogram, biochemical and hematological data were recorded before and at intervals after injection. No significant changes were observed. Seventeen volunteers reported no side effects; six volunteers had mild transitory symptoms considered to be related to the contrast medium. The authors conclude that broader clinical trials can be safely conducted to determine safety and tolerability of ioversol. |
| Databáze: | OpenAIRE |
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