3D Printing for Bio-Synthetic Biliary Stents
| Autor: | Boyer, Christen J., Boktor, Moheb, Samant, Hrishikesh, White, Luke, Wang, Yuping, Ballard, David, Huebert, Robert, Woerner, Jennifer E., Ghali, G.E., Alexander, Jonathan Steven |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
3D printing Design elements and principles Bioengineering 02 engineering and technology Polyvinyl alcohol lcsh:Technology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tissue engineering stem cells Medicine cardiovascular diseases lcsh:QH301-705.5 hepatobiliary stent business.industry Bile duct medical device lcsh:T Stent personalized medicine 021001 nanoscience & nanotechnology equipment and supplies 3. Good health medicine.anatomical_structure surgical procedures operative tissue engineering chemistry lcsh:Biology (General) Biliary stent 030211 gastroenterology & hepatology 0210 nano-technology business Biofabrication Biomedical engineering |
| Zdroj: | Bioengineering, Vol 6, Iss 1, p 16 (2019) Bioengineering Volume 6 Issue 1 Bioengineering, 6(1):16 |
| ISSN: | 2306-5354 |
| Popis: | Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. The biofabrication method in the present study examined 3D printing and collagen injection molding for rapid prototyping of customized living biliary stents with clinical applications in the setting of malignant and benign bile duct obstructions. XL-PVA stents showed hydrophilic swelling and addition of radiocontrast to the stent matrix improved radiographic opacity. Collagen loaded with PMSCs contracted tightly around hydrophilic stents and dense choloangiocyte coatings were verified through histology and fluorescence microscopy. It is anticipated that design elements used in these stents may enable appropriate stent placement, provide protection of the stent-stem cell matrix against bile constituents, and potentially limit biofilm development. Overall, this approach may allow physicians to create personalized bio-integrating stents for use in biliary procedures and lays a foundation for new patient-specific stent fabrication techniques. |
| Databáze: | OpenAIRE |
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