Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon
| Autor: | Marli S. Santana, Marcus Vinícius Guimarães de Lacerda, Monica R. F. Costa, André M. Siqueira, Maria das Graças Costa Alecrim, Vanderson de Souza Sampaio, Wuelton M. Monteiro |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Primaquine Blood transfusion Adolescent Cross-sectional study medicine.medical_treatment Plasmodium vivax Lower risk Young Adult Internal medicine parasitic diseases medicine Prevalence Humans Young adult Child Aged Genetics biology business.industry Public Health Environmental and Occupational Health Genetic Variation Infant General Medicine Middle Aged medicine.disease biology.organism_classification Malaria Infectious Diseases Cross-Sectional Studies Glucosephosphate Dehydrogenase Deficiency Latin America Child Preschool Parasitology Disease Susceptibility business Brazil medicine.drug |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 107(5) |
| ISSN: | 1878-3503 |
| Popis: | BACKGROUND: Glucose-6-phosphate dehydrogenase deficiency (G6PDd) has been shown to protect against malaria infection and severe manifestations in African and Asia, but there is a scarcity of studies in the Americas. This study aimed to study the prevalence of G6PDd and its association with malaria occurrence in the Brazilian Amazon. METHODS: A cross-sectional study was conducted in the male population to estimate the prevalence of G6PDd and malaria infection. G6PD deficient samples were genotyped to identify the deficient variant. Number of previous malaria episodes and need for blood transfusion during malaria episodes were recorded by applying a standardized questionary. RESULTS: From a sample of 1478 male individuals, 66 were detected as G6PD deficient, resulting in a prevalence of of 4.5% (95% CI = 3.44-5.56%). Fifty six G6PD deficient individuals (3.8%; 95% CI = 2.82-4.77) presented the G6PD A-variant mutation, while 10 individuals (0.7%; 95% CI = 0.42-0.97) severely deficient were genotyped as carriers of the G6PD Mediterranean variant. After adjusting for age, G6PD deficient individuals were less likely to report the occurrence of malaria episodes, and the protective effect was related to the enzyme activity, with carriers of the GG6PD A-variant presenting a 88% reduction (AOR: 0.119; 95% CI = 0.057-0.252; p < 0.001) and carriers of the Meditarrenean variant presenting 99% lower risk (AOR: 0.010; 95% CI = 0.002-0.252; p < 0.001) when compared to non-deficient individuals. On the other hand, G6PD deficient subjects reported higher need of transfusion during malaria episodes (p < 0.001). CONCLUSION: G6PD enzyme activity was directly related to susceptibility to malaria in the Brazilian Amazon, where P. vivax predominates. Severe G6PDd was associated with considerable higher risk of malaria-related transfusions. |
| Databáze: | OpenAIRE |
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