Inhibition of prostaglandin synthesis by indomethacin interacts with the antihypertensive effect of atenolol
| Autor: | Nurmi Ak, Pauli Ylitalo, Erkki Seppälä, M.-L. Pyykönen, Timo Pitkäjärvi, Heikki Vapaatalo |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Indomethacin Radioimmunoassay Prostaglandin Prostacyclin Blood Pressure 6-Ketoprostaglandin F1 alpha Pharmacology Essential hypertension Plasma renin activity Dinoprostone Excretion Renin-Angiotensin System chemistry.chemical_compound Heart Rate Internal medicine Renin medicine Humans Pharmacology (medical) Drug Interactions Kininogen Kininogens Prostaglandins E Prostaglandin antagonist Middle Aged Atenolol medicine.disease Thromboxane B2 Endocrinology chemistry Hypertension Prostaglandins lipids (amino acids peptides and proteins) Kallikreins circulatory and respiratory physiology medicine.drug Glomerular Filtration Rate |
| Zdroj: | Clinical pharmacology and therapeutics. 38(4) |
| ISSN: | 0009-9236 |
| Popis: | The interaction of inhibition of prostaglandin (PG) synthesis by indomethacin (75 mg/day) with the antihypertensive effect of atenolol (50 mg b.i.d.) was studied in 11 untreated otherwise healthy men 35 to 45 years old with essential hypertension. Atenolol for 3 weeks decreased supine blood pressure (BP) from 157/109 mm Hg during placebo to 148/97 mm Hg. Indomethacin alone for 1 week slightly increased BP and antagonized the antihypertensive action of atenolol. Atenolol reduced plasma renin activity (PRA) to 40% but did not modify either the urinary excretion of vasodilatory PGs (PGE2 and prostacyclin measured as 6-keto-PGF1α) or plasma kininogen and urine kallikrein. Indomethacin suppressed PRA to 27% and PG excretion to approximately 70% but did not markedly change plasma kininogen and urine kallikrein excretion. The decreased excretion of 6-keto-PGF1α, the metabolite of the main vasodilatory prostanoid prostacyclin, correlated with the increased BP measured in standing subjects. The effects of indomethacin were practically the same when given with atenolol as when given alone. We conclude that the slight increase in BP by indomethacin in essential hypertension is associated with the reduced production of vasodilatory PGs but not with alterations in activities of the renin-angiotensin or kallikreinkinin systems. Clinical Pharmacology and Therapeutics (1985) 38, 443–449; doi:10.1038/clpt.1985.202 |
| Databáze: | OpenAIRE |
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