Wound healing activity of Persea americana (avocado) fruit: a preclinical study on rats
| Autor: | S.S. Raju, A.V. Chalapathi Rao, B S Nayak |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Persea medicine.medical_specialty Oral treatment Nursing (miscellaneous) Administration Oral Wounds Penetrating Topical treatment Administration Cutaneous Ointments Rats Sprague-Dawley Hydroxyproline chemistry.chemical_compound Oral administration Animals Medicine Analysis of Variance Wound Healing integumentary system biology Traditional medicine Plant Extracts business.industry Granulation tissue biology.organism_classification Rats Surgery Disease Models Animal medicine.anatomical_structure chemistry Fruit Granulation Tissue Drug Evaluation Fundamentals and skills business Wound healing Excision wound Phytotherapy |
| Zdroj: | Journal of Wound Care. 17:123-125 |
| ISSN: | 2052-2916 0969-0700 |
| DOI: | 10.12968/jowc.2008.17.3.28670 |
| Popis: | Objective: Avocado (Persea americana) oil is rich in nutrient waxes, proteins and minerals, as well as vitamins A, D and E. It is an excellent source of enrichment for dry, damaged or chapped skin. This study aimed to evaluate the wound-healing activity of fruit extract of Persea americana in rats. Method: The effect of topical and oral administration of Persea americana fruit extract (300mg/kg/day) on excision and dead space wound models was evaluated. The rats used in the excision wound model were divided into four groups of five each and received either topical or oral treatment. The rats used in the dead space wound model were divided into two groups of five each and were treated orally. Healing was assessed by the rate of wound contraction, period of epithelialisation, granulation tissue weight and hydoxyproline content. Results: In the excision wound model, complete healing (full epithelialisation) was observed on average on day 14 in the rats who receive oral or topical treatment. In contrast, the controls took approximately 17 days to heal completely. The extract-treated wounds were found to epithelialise faster than the controls (pConclusion: Rate of wound contraction, epithelialisation time together with the hydroxyproline content and histological observations support the use of Persea americana in the management of wound healing. Declaration of interest: None. |
| Databáze: | OpenAIRE |
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