Impact of procalcitonin on the management of children aged 1 to 36 months presenting with fever without source: A randomized controlled trial
| Autor: | Edgard Delvin, Jocelyne Cousineau, Annick Galetto-Lacour, Sergio Manzano, Benoit Bailey, Jean-Bernard Girodias |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pediatrics
medicine.medical_specialty Fever of Unknown Origin/*blood/etiology/*therapy Bacterial Infections/complications/*diagnosis/*drug therapy ddc:616.0757 Procalcitonin law.invention Cohort Studies Randomized controlled trial Predictive Value of Tests law Intensive care parasitic diseases medicine Humans Blood culture ddc:618 medicine.diagnostic_test Lumbar puncture business.industry Infant Reproducibility of Results Complete blood count General Medicine bacterial infections and mycoses medicine.disease Anti-Bacterial Agents/*therapeutic use Hospitalization Pneumonia Treatment Outcome Protein Precursors/*blood Child Preschool Bacteremia Emergency Medicine Emergency Service Hospital business Calcitonin/*blood hormones hormone substitutes and hormone antagonists |
| Zdroj: | The American Journal of Emergency Medicine, Vol. 28, No 6 (2010) pp. 647-653 |
| ISSN: | 0735-6757 |
| Popis: | OBJECTIVE: The aim of the study was to evaluate the impact of procalcitonin (PCT) measurement on antibiotic use in children with fever without source. METHOD: Children aged 1 to 36 months presenting to a pediatric emergency department (ED) with fever and no identified source of infection were eligible to be included in a randomized controlled trial. Patients were randomly assigned to 1 of 2 groups as follows: PCT+ (result revealed to the attending physician) and PCT- (result not revealed). Patients from both groups also had complete blood count, blood culture, urine analysis, and culture performed. Chest radiography or lumbar puncture could be performed if required. RESULTS: Of the 384 children enrolled and equally randomized into the PCT+ and PCT- groups, 62 (16%) were diagnosed with a serious bacterial infection (urinary tract infection, pneumonia, occult bacteremia, or bacterial meningitis) by primary ED investigation. Ten were also found to be neutropenic ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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