Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles

Autor: Amos A. Fatokun, Christopher R. Coxon, Touraj Ehtezazi, Muttuswamy Sivakumaran, Meritxell Teixidò, Yamir Islam, J. E. G. Downing, Andrew G. Leach, Stefano Pluchino, Jayden Smith
Přispěvatelé: Ehtezazi, Touraj [0000-0002-1576-2396], Apollo - University of Cambridge Repository
Rok vydání: 2021
Předmět:
Aging
Science
General Chemical Engineering
Drug delivery to the brain
Reviews
General Physics and Astronomy
Medicine (miscellaneous)
Context (language use)
Review
02 engineering and technology
Disease
immunogenicity
010402 general chemistry
01 natural sciences
Biochemistry
Genetics and Molecular Biology (miscellaneous)
RS
Drug Delivery Systems
Medicine
Aging brain
Humans
General Materials Science
neurodegenerative diseases
Pathological
blood-brain barrier model
complement activation
Brain Diseases
blood–brain barrier model
Mechanism (biology)
business.industry
General Engineering
Brain
drug delivery to the brain
021001 nanoscience & nanotechnology
QP
0104 chemical sciences
Brain targeting
Blood-Brain Barrier
Drug delivery
Nanoparticles
nanoparticles
0210 nano-technology
business
Neuroscience
aging brain
Zdroj: Islam, Y, Leach, A G, Smith, J, Pluchino, S, Coxon, C R, Sivakumaran, M, Downing, J, Fatokun, A A, Teixidò, M & Ehtezazi, T 2021, ' Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles ', Advanced Science . https://doi.org/10.1002/advs.202002085
Advanced Science, Vol 8, Iss 11, Pp n/a-n/a (2021)
Advanced Science
ISSN: 2198-3844
DOI: 10.17863/cam.71078
Popis: The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is known to be increasing due to an aging population and is anticipated to further grow in the decades ahead. The treatment of brain diseases is challenging partly due to the inaccessibility of therapeutic agents to the brain. An increasingly important observation is that the physiology of the brain alters during many brain diseases, and aging adds even more to the complexity of the disease. There is a notion that the permeability of the blood–brain barrier (BBB) increases with aging or disease, however, the body has a defense mechanism that still retains the separation of the brain from harmful chemicals in the blood. This makes drug delivery to the diseased brain, even more challenging and complex task. Here, the physiological changes to the diseased brain and aged brain are covered in the context of drug delivery to the brain using nanoparticles. Also, recent and novel approaches are discussed for the delivery of therapeutic agents to the diseased brain using nanoparticle based or magnetic resonance imaging guided systems. Furthermore, the complement activation, toxicity, and immunogenicity of brain targeting nanoparticles as well as novel in vitro BBB models are discussed.
The treatment of brain diseases is challenging partly due to the inaccessibility of therapeutic agents to the brain. The physiology of the brain alters during neurological diseases, making treatment challenging. Nanoparticles are novel method of drug delivery, however, an understanding of biological responses such as immunogenicity and toxicity is essential for safe application.
Databáze: OpenAIRE
Externí odkaz: