Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms
| Autor: | Graham Packham, Alison Yeomans, Joe Taylor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine mRNA translation Chronic lymphocytic leukemia Follicular lymphoma lymphoma Biology Article 03 medical and health sciences 0302 clinical medicine Eukaryotic initiation factor medicine Protein biosynthesis Initiation factor lcsh:RC31-1245 Tumor microenvironment leukemia drug Translation (biology) medicine.disease initiation inhibitor Leukemia 030104 developmental biology 030220 oncology & carcinogenesis Cancer research |
| Zdroj: | Exploration of targeted anti-tumor therapy Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 1, Pp 3-25 (2020) |
| ISSN: | 2692-3114 |
| Popis: | Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins. Thus, targeted inhibition of mRNA translation is viewed as a promising new approach for cancer therapy. In this article we review current progress in investigating dysregulation of mRNA translation initiation in mature B-cell neoplasms, focusing on chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma. We discuss mechanisms and regulation of mRNA translation, potential pathways by which genetic alterations and the tumor microenvironment alters mRNA translation in malignant B cells, preclinical evaluation of drugs targeted against specific eukaryotic initiation factors and current progress towards clinical development. Overall, inhibition of mRNA translation initiation factors is an exciting and promising area for development of novel targeted anti-tumor drugs. |
| Databáze: | OpenAIRE |
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