Erythrocyte membranes beta-adrenoreactivity changes after renal denervation in patients with resistant hypertension, relationship with antihypertensive and cardioprotective intervention efficacy
| Autor: | M. Manukyan, S. E. Pekarskij, S. A. Afanasiev, I. G. Shalishev, E. F. Muslimova, I. V. Zyubanova, T. Yu. Rebrova, A. Yu. Falkovskaya, V. Lichikaki, Viktor Mordovin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Denervation medicine.medical_specialty business.industry Erythrocyte Membrane Resistant hypertension Blood Pressure Middle Aged Erythrocyte hemolysis Treatment Outcome Blood pressure Endocrinology Internal medicine Hypertension Renin–angiotensin system medicine Humans Sympathoadrenal system In patient Cardiology and Cardiovascular Medicine business Beta (finance) Antihypertensive Agents Aged |
| Zdroj: | Kardiologiia. 61:32-39 |
| ISSN: | 2412-5660 0022-9040 |
| Popis: | Aim To study the functional condition of sympathoadrenal system as evaluated by beta-adrenoreactivity of erythrocyte membranes (beta-ARM) during two years following renal denervation (RD) in patients with resistant arterial hypertension (RAH) and to determine the relationship of this index with long-term antihypertensive and cardioprotective effectivity of this invasive treatment.Material and methods The study included 48 patients (mean age, 57.2±8.7 years, 18 men) with RAH on a stable antihypertensive therapy. Averaged daily systolic and diastolic blood pressure (SBP and DBP) and levels of beta-ARM were determined at baseline and in 7 days and 2 years following RD. Measurement of beta-ARM was based on beta-adrenoblocker inhibition of erythrocyte hemolysis induced by exposure to hypo-osmotic environment. The beta-adrenoblocker binds to erythrocyte membrane beta-adrenoceptors to prevent the erythrocyte destruction. Increased values of beta-ARM reflect a decrease in the number of functionally active erythrocyte membrane beta-adrenoceptors associated with long-term sympathetic hyperactivity.Results For two years of follow-up, values of average daily BP decreased from 160.4±16.0 / 88.1±14.6 to 145.3±19.3 / 79.4±13.6 mm Hg. At 7 days, the number of beta-ARM had decreased in the group of RD responders (р=0.028) who at two years had decreased their BP by 10 mm Hg or more, while in the group of non-responders, the number of beta-ARM remained unchanged. At one week, beta-ARM values correlated with changes in SBP and DBP (r= –0.54; рConclusion The decrease in beta-ARM content at 7 days after RD shows the procedure efficacy and allows an expectation of clinically significant decreases in BP and LVMM in the long-term after the surgical treatment. At two years after the intervention, the content of beta-ARM increased, and the BP decrease was apparently due to some other mechanisms. |
| Databáze: | OpenAIRE |
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