Effect of Helicobacter pylori eradication therapy on clinical and laboratory biomarkers associated with gastric damage in healthy school-aged children: A randomized non-blinded trial

Autor:	Juan Pablo Torres, Yalda Lucero, Mónica González, Nicole Huerta, Anne J. Lagomarcino, Patricia Roessler, Miguel O'Ryan G, Sergio George, Nora Mamani
Rok vydání:	2021
Předmět:	Adult medicine.medical_specialty Nausea Urea breath test macromolecular substances Asymptomatic Gastroenterology Helicobacter Infections Pepsin Internal medicine Clarithromycin medicine Pepsinogen C Humans Child School age child Schools biology medicine.diagnostic_test Helicobacter pylori business.industry Cancer Amoxicillin General Medicine biology.organism_classification medicine.disease Anti-Ulcer Agents Anti-Bacterial Agents Diarrhea Infectious Diseases Child Preschool biology.protein Drug Therapy Combination medicine.symptom business Laboratories Biomarkers
Zdroj:	HelicobacterREFERENCES. 26(6)
ISSN:	1523-5378
Popis:	OBJECTIVES Helicobacter pylori (H. pylori) is the primary cause of gastric cancer and eradication in healthy adults has proven effective in decreasing cancer incidence. H. pylori is acquired largely in early childhood, however, the benefits of eradication in children are controversial. We aimed to determine the effect of H. pylori eradication on clinical and laboratory markers associated with gastric damage in apparently healthy school-aged children. METHODS This was a pilot non-blinded trial including 61 children persistently infected with H. pylori who were randomized to eradication/no treatment and followed for at least 12 months, evaluating clinical and blood markers (Pepsinogen I (PGI) and II (PGII) determined by ELISA) associated with gastric damage. The treatment consisted of a sequential scheme including 7 days of omeprazole + amoxicillin followed by 7 days of omeprazole + clarithromycin + metronidazole; adherence and tolerance were surveyed. Eradication rates were assessed by stool antigen detection or urea breath test 1 month following treatment every 4 months thereafter to detect reinfection. RESULTS Eradication occurred in 30/31 treated children (median age: 8.8, range: 7.9-10.8) and in 0/30 non-treated controls (median age: 8.6, range: 7.9-11) (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358093b72fc0cf234d69e0fac4d7a4e3 https://pubmed.ncbi.nlm.nih.gov/36114816 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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