The Search for Citrus Components with Neuroprotective and Anti-dementia Effects in the Mouse Brain
| Autor: | Mitsunari Nakajima, Satoshi Okuyama, Yoshiko Furukawa, Atsushi Sawamoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Citrus
Tau protein Anti-Inflammatory Agents Pharmaceutical Science Hyperphosphorylation Hippocampus tau Proteins Pharmacology Hippocampal formation Neuroprotection Brain Ischemia Neurotrophic factors Animals Nootropic Agents Flavonoids Memory Disorders Cell Death biology Chemistry Dentate gyrus Neurogenesis Mice Inbred C57BL Disease Models Animal Neuroprotective Agents biology.protein Dementia Microglia Phytotherapy |
| Zdroj: | YAKUGAKU ZASSHI. 141:819-824 |
| ISSN: | 1347-5231 0031-6903 |
| DOI: | 10.1248/yakushi.20-00251-1 |
| Popis: | Citrus kawachiensis (Kawachi Bankan), is a citrus species grown in Ehime, Japan, and its peel is abundant in 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF). We have recently revealed that HMF, one of the citrus flavonoids, has anti-inflammatory activity and neuroprotective abilities in the brain against global cerebral ischemia. HMF rescued neuronal cell death in the hippocampus and suppressed the activation of microglia, whose activation have been shown to significantly aggravate neurological deficit scores for ischemic mice. In the Y-maze test, HMF showed protection against ischemia-induced short-term memory dysfunction; in addition, HMF enhanced the expression of brain-derived neurotrophic factor and accelerated neurogenesis in the hippocampus. Similarly, the powder of the peel of C. kawachiensis showed anti-inflammatory activity and neuroprotective abilities in the ischemic brain. To further examine the effect of the peel of C. kawachiensis, we administered it to senescence-accelerated-mouse prone 8 (SAMP8) mice, which show memory impairment and brain inflammation, tau hyperphosphorylation, and neuronal dysfunction. The C. kawachiensis treatment inhibited microglial activation and the hyperphosphorylation of tau protein in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in SAMP8. These results suggest that HMF and the peel of C. kawachiensis have potential effects as neuroprotective and anti-dementia agents. |
| Databáze: | OpenAIRE |
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