Endovascular treatment of hepatocellular carcinoma with drug eluting microparticles (DC-Beads): CT evaluation of response to the treatment
| Autor: | Mario Corona, Alessandro Cannavale, Carlo Cirelli, Lorenzo de Medici, Fabrizio Fanelli, Emanuele Boatta |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Drug
medicine.medical_specialty business.industry media_common.quotation_subject R895-920 computed tomography hepatocellular carcinoma medicine.disease Medical physics. Medical radiology. Nuclear medicine Tolerability Response Evaluation Criteria in Solid Tumors Hepatocellular carcinoma Multidetector computed tomography Vascular and Interventional Radiology Mini Symposia Medicine Chemoembolization Radiology Nuclear Medicine and imaging Radiology Endovascular treatment business Progressive disease Complete response media_common |
| Zdroj: | The Indian Journal of Radiology & Imaging Indian Journal of Radiology and Imaging, Vol 23, Iss 02, Pp 126-133 (2013) |
| ISSN: | 1998-3808 0971-3026 |
| DOI: | 10.4103/0971-3026.116564 |
| Popis: | Background and Study Aims: Our aim was to assess the efficacy and tolerability of drug-eluting beads-transarterial chemoembolization (DEB-TACE) in the treatment of hepatocellular carcinoma (HCC), evaluating the response to the treatment after 1, 6, 12, and 24 months with multidetector computed tomography (MDCT) comparing European Association for the study of the Liver (EASL) and modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. Materials and Methods: We enrolled 154 patients with uni- or multifocal HCC who underwent a DEB-TACE. A total of 278 HCC nodules were treated. CT follow-up was performed at 1, 6, 12, and 24 months after the procedure according to the EASL and RECIST criteria evaluating overall target and target nodule response. We also analyzed the shrinking of nodules in relation to response to treatment. Results: A total of 278 nodules of HCC underwent TACE by using DC-Beads: At 24, months complete response was similar for EASL and RECIST criteria (112 vs. 121 nodules) with optimal accordance between methods and readers with k = 0.9. Partial Response resulted significantly different among the two methods within the first month, otherwise was similar after 24-month follow-up. Similar results in both methods were found for nodules classified as Stable Disease (P > 0.05). Progressive Disease results were similar in both the groups according to both the classification criteria without any significant difference (P > 0.05). Conclusion: Our study confirmed that EASL and mRECIST criteria are both effective methods for patient follow-up, however with some technical differences. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|