Rabeprazole sodium delayed-release multiparticulates: Effect of enteric coating layers on product performance
| Autor: | Prashant Puranik, Rakesh N Tirpude |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Materials science
Inorganic chemistry Pellets lcsh:RS1-441 engineering.material Dosage form Enteric lcsh:Pharmacy and materia medica Coating delayed-release Pellet medicine Dissolution testing Rabeprazole Sodium chemistry.chemical_classification rabeprazole sodium lcsh:RM1-950 multiparticulates Polymer Enteric coating lcsh:Therapeutics. Pharmacology chemistry Chemical engineering engineering Original Article proton pump inhibitors medicine.drug |
| Zdroj: | Journal of Advanced Pharmaceutical Technology & Research Journal of Advanced Pharmaceutical Technology & Research, Vol 2, Iss 3, Pp 184-191 (2011) |
| ISSN: | 0976-2094 2231-4040 |
| Popis: | Rabeprazole sodium is one of the most effective proton pump inhibitors (PPIs) used in antiulcer therapy. Like most other PPIs, owing to its acid-labile nature, the drug is formulated as enteric-coated dosage form. Conventional means of producing delayed release multiparticulate dosage forms of PPIs require large quantities of enteric polymer coatings. In the present study, in order to better evaluate the effect of polymeric coating on product performance, the pellet core structure and composition was kept constant. Four different enteric-coating formulations and designs were evaluated. Enteric-coated drug multiparticulates prepared with single polymeric coatings (acrylic or cellulosic) were compared with two different polymeric layer coatings to evaluate the effectiveness of latter coatings in more effectively producing a better rabeprazole sodium delayed-release pellet product. The pH-dependent, enteric acrylic, and cellulosic polymers were used either alone, in combination, or applied one over the other to impart delayed-release properties to the core drug pellets. It was demonstrated that dual delayed-release coating with two different enteric polymers-an inner acrylic coating followed by an outer cellulosic coating-yields the best product that provides all the desired physicochemical and drug dissolution characteristics. |
| Databáze: | OpenAIRE |
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