Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses
| Autor: | Leila Kara, Issa Ouedraogo, Herman Oostermeijer, Edmond J. Remarque, Sophie Houard, Odile Leroy, Roberto Rodriguez Garcia, Bart W. Faber, Sodiomon B. Sirima, Clemens H. M. Kocken, Odile Launay |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein vaccines 030231 tropical medicine Immunology Placebo Article 03 medical and health sciences 0302 clinical medicine Immune system Antigen parasitic diseases Medicine Pharmacology (medical) Apical membrane antigen 1 RC254-282 Pharmacology biology business.industry Malaria vaccine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Plasmodium falciparum RC581-607 biology.organism_classification Malaria Vaccination 030104 developmental biology Infectious Diseases Cohort Immunologic diseases. Allergy business |
| Zdroj: | NPJ Vaccines npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2059-0105 |
| Popis: | Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1’s polymorphic nature impacts vaccine-induced protection. To address polymorphism, three Diversity Covering (DiCo) protein sequences were designed and tested in a staggered phase Ia/b trial. A cohort of malaria-naive adults received PfAMA1-DiCo adjuvanted with Alhydrogel® or GLA-SE and a cohort of malaria-exposed adults received placebo or GLA-SE adjuvanted PfAMA1 DiCo at weeks 0, 4 and 26. IgG and GIA levels measured 4 weeks after the third vaccination are similar in malaria-naive volunteers and placebo-immunised malaria-exposed adults, and have a similar breadth. Vaccination of malaria-exposed adults results in significant antibody level increases to the DiCo variants, but not to naturally occurring PfAMA1 variants. Moreover, GIA levels do not increase following vaccination. Future research will need to focus on stronger adjuvants and/or adapted vaccination regimens, to induce potentially protective responses in the target group of the vaccine. |
| Databáze: | OpenAIRE |
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