Treponema denticolachymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features

Autor: Dan Nordström, Marcela Hernández, Daniel Grenier, Taina Tervahartiala, Laura K. Mäkinen, Valtteri Häyry, Jaana Hagström, Tuelay Yucel-Lindberg, Timo Sorsa, Caj Haglund, Dyah Listyarifah, Mari Ainola, Mikko T. Nieminen
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
Virulence Factors
medicine.disease_cause
Pathology and Forensic Medicine
Proto-Oncogene Proteins c-myc
03 medical and health sciences
0302 clinical medicine
Tongue
Carcinoma
medicine
Chymotrypsin
Humans
Neoplasm Invasiveness
Periodontitis
Receptor
Pathological
Aged
Neoplasm Staging
Treponema
biology
business.industry
Toll-Like Receptors
Cancer
Treponema denticola
Middle Aged
medicine.disease
biology.organism_classification
Immunohistochemistry
Matrix Metalloproteinases
Tongue Neoplasms
3. Good health
030104 developmental biology
medicine.anatomical_structure
Otorhinolaryngology
030220 oncology & carcinogenesis
Proteolysis
Carcinoma
Squamous Cell
Periodontics
Female
Oral Surgery
Carcinogenesis
business
Peptide Hydrolases
Zdroj: Journal of Oral Pathology & Medicine. 47:764-772
ISSN: 0904-2512
DOI: 10.1111/jop.12729
Popis: Background Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However, the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics. Methods The immunopositivity of Td-CTLP was assessed in samples obtained from 60 patients with MTSCC and associated with their clinicopathological data. Additionally, Td-CTLP expression was compared with immunoexpression of matrix metalloproteinases (MMP-8 and MMP-9), toll-like receptors (TLR-2, TLR-4, TLR-7 and TLR-9), c-Myc, Ki-67, Bmi-1 and Snail. Results Treponema denticola-chymotrypsin-like proteinase was present in 95% of MTSCC tumours of which many (40.4%) showed high immunopositivity. Td-CTLP positivity was significantly associated with invasion depth, tumour diameter and the expression of TLR-7, TLR-9 and c-Myc. High Td-CTLP immunopositivity in younger patients (≤ 60 years old) predicted early relapse. Conclusion Our data indicate that Td and its CTLP are present in early-stage MTSCC carcinoma and may contribute to carcinogenesis, and therefore provide novel perspectives into intervention and therapeutic measures of MTSCC.
Databáze: OpenAIRE
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