Regional glycine receptor binding in the p,p'-DDT myoclonic rat model
| Autor: | Michael R. Pranzatelli, Katie Tkach |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Myoclonus medicine.medical_specialty animal structures Health Toxicology and Mutagenesis Glycine Receptor Binding Neurotransmission Toxicology DDT chemistry.chemical_compound Receptors Glycine Internal medicine parasitic diseases medicine Animals Neurotransmitter metabolism Glycine receptor reproductive and urinary physiology Chemistry organic chemicals Rats Inbred Strains General Medicine Strychnine Spinal cord Rats Receptors Neurotransmitter Disease Models Animal Endocrinology medicine.anatomical_structure Spinal Cord Glycine medicine.symptom geographic locations Brain Stem |
| Zdroj: | Archives of toxicology. 66(1) |
| ISSN: | 0340-5761 |
| Popis: | Abnormal glycinergic neurotransmission has been implicated in the pathophysiology of DDT-induced myoclonus. To examine the role of glycine receptors in the DDT model, was measured [3H]strychnine receptor binding in brainstem and spinal cord in the rat after acute administration of DDT. The highest dose of DDT tested significantly increased both Bmax (20%) and Kd (57%) of glycine sites in spinal cord but not brainstem compared to vehicle-treated controls at 4 h. Lower DDT doses, which also induced myoclonus, had no significant effects on [3H]strychnine specific binding. In vitro, 10(-7) DDT did not displace [3H]strychnine binding in naive rat spinal cord, but higher doses could not be studied due to poor solubility of DDT under the assay conditions. These data suggest that only a maximal dose of DDT has significant though mixed effects on parameters of [3H]strychnine binding in spinal cord which are not correlated with the onset of myoclonus. |
| Databáze: | OpenAIRE |
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