Efficient myogenic reprogramming of adult white fat stem cells and bone marrow stem cells by freshly isolated skeletal muscle fibers
| Autor: | Steve Ray, Ketan Patel, Mark Cranfield, William R. Otto, Henry Collins-Hooper, Graham Luke |
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| Rok vydání: | 2011 |
| Předmět: |
Adipose Tissue
White Green Fluorescent Proteins Muscle Fibers Skeletal Clinical uses of mesenchymal stem cells Bone Marrow Cells Cell Communication Intra-Abdominal Fat Biology Mesenchymal Stem Cell Transplantation Muscle Development Physiology (medical) Animals Rats Wistar Cells Cultured Stem cell transplantation for articular cartilage repair Induced stem cells Biochemistry (medical) Public Health Environmental and Occupational Health Bone Marrow Stem Cell Cell Differentiation Mesenchymal Stem Cells Amniotic stem cells General Medicine Molecular biology Rats Cell biology Endothelial stem cell Adult Stem Cells Muscular Atrophy Female Rats Transgenic Stem cell Adult stem cell |
| Zdroj: | Translational Research. 158:334-343 |
| ISSN: | 1931-5244 |
| DOI: | 10.1016/j.trsl.2011.07.009 |
| Popis: | Stem cells that can be directed to differentiate into specific cell types offer the prospect of a renewable source of replacement cells to treat diseases. This study evaluates the reprogramming of 2 readily available stem cell populations into skeletal muscle. We show for the first time that freshly isolated muscle fibers reprogram bone marrow or white fat stem cells far more efficiently than muscle cell lines. In addition, we show that the ability of muscle fibers to reprogram stem cells can be almost doubled through the use of chromatin remodeling reagents such as trichostatin A. This novel approach permits the generation of myogenic cells that could be used to treat a range of muscle-wasting diseases. |
| Databáze: | OpenAIRE |
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