Magnetic resonance imaging of haemorrhage within reperfused myocardial infarcts: possible interference with iron oxide-labelled cell tracking?
| Autor: | Willem J. van der Giessen, Timo Baks, Robert-Jan van Geuns, Dirk J. Duncker, Wendy Kerver, A. Moelker, E. Bos, Piotr A. Wielopolski |
|---|---|
| Přispěvatelé: | Cardiology, Radiology & Nuclear Medicine |
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Swine Myocardial Infarction Infarction Contrast Media Hemorrhage Myocardial Reperfusion Ferric Compounds Reperfusion therapy Occlusion medicine Animals Myocardial infarction medicine.diagnostic_test business.industry Microcirculation Magnetic resonance imaging medicine.disease Circulatory system Cardiology and Cardiovascular Medicine business Nuclear medicine Perfusion Ex vivo Magnetic Resonance Angiography |
| Zdroj: | European Heart Journal, 27(13), 1620-1626. Oxford University Press |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Aims Magnetic resonance imaging (MRI) has been proposed as a tool to track iron oxide-labelled cells within myocardial infarction (MI). However, infarct reperfusion aggravates microvascular obstruction (MO) and causes haemorrhage. We hypothesized that haemorrhagic MI causes magnetic susceptibility-induced signal voids that may interfere with iron oxide-labelled cell detection. Methods and results Pigs (n ¼ 23) underwent 2 h occlusion of the left circumflex artery. Cine, T2*-weighted, perfusion, and delayed enhancement MRI scans were performed at 1 and 5 weeks, followed by ex vivo high-resolution scanning. At 1 week, MO was observed in 17 out of 21 animals. Signal voids were observed on T2*-weighted scans in five out of eight animals, comprising 24+ 22% of the infarct area. A linear correlation was found between area of MO and signal voids (R 2 ¼ 0.87; P ¼ 0.002). At 5 weeks, MO was observed in two out of 13 animals. Signal voids were identified in three out of seven animals. Ex vivo scanning showed signal voids on T2*-weighted scanning in all animals because of the presence of haemorrhage, as confirmed by histology. Signal voids interfered with the detection of iron oxide-labelled cells ex vivo (n ¼ 21 injections). Conclusion Haemorrhage in reperfused MI produces MRI signal voids, which may hamper tracking of iron oxide-labelled cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|