Systemic lupus erythematosus associated with acute Epstein-Barr virus infection
| Autor: | Patrizia Cohen, Azaria Ashkenazi, Yigal Dror, Eliezer Rosenmann, Yoram Blachar, Nelly Livni |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Adolescent Mononucleosis Biopsy Kidney medicine.disease_cause Virus Herpesviridae Autoimmune Diseases Pathogenesis Glomerulonephritis immune system diseases hemic and lymphatic diseases Humans Lupus Erythematosus Systemic Medicine Infectious Mononucleosis skin and connective tissue diseases Antigens Viral Epstein–Barr virus infection Autoimmune disease Lupus erythematosus business.industry medicine.disease Epstein–Barr virus Virology Nephrology Acute Disease Immunology Female business |
| Zdroj: | American Journal of Kidney Diseases. 32:825-828 |
| ISSN: | 0272-6386 |
| DOI: | 10.1016/s0272-6386(98)70140-4 |
| Popis: | Systemic lupus erythematosus (SLE) is a multisystem disease of unknown origin, characterized by a variety of autoimmune phenomena. Viruses have long been postulated to play a role in its pathogenesis. Several observations suggested a link between Epstein-Barr virus (EBV) and SLE. We describe a 14-year-old girl who presented with acute onset of SLE concurrently with clinical and laboratory findings consistent with EBV-induced infectious mononucleosis (IM). Evidence for acute EBV infection was confirmed by serological studies and detection of specific EBV antigens on kidney biopsy. This close association between EBV and SLE suggests a possible role of the virus in the pathogenesis of SLE in this patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|