From palliative to curative treatment - stage IV mucinous adenocarcinoma, successfully treated with metronomic capecitabine in combination with Bevacizumab and surgery- a case report
| Autor: | Karolina Vernmark, Annika Holmqvist, Bergthor Björnsson, Maria Albertsson, Xiao-Feng Sun, Thomas Gasslander, Per Sandström |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Cancer Research Palliative care Bevacizumab Colorectal cancer Leucovorin Case Report Mucinous adenocarcinoma Bevaczumab Metronomic capecitabine Capecitabine Folinic acid Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Genetics Humans Performance status business.industry Palliative Care Klinisk medicin medicine.disease Adenocarcinoma Mucinous Oxaliplatin Surgery Female Fluorouracil Neoplasm Recurrence Local Clinical Medicine business Chemoradiotherapy medicine.drug |
| Zdroj: | BMC Cancer |
| Popis: | Background: Mucinous adenocarcinoma (MAC) represents 6-19 % of all colorectal carcinoma. It is associated with poorer response to chemotherapy and chemoradiotherapy. Case presentation: A 27-year-old Swedish woman presented with stomach pain and weight loss, and was diagnosed with locally advanced MAC in the transverse colon as well as 3 liver metastases. Neoadjuvant treatment with fluorouracil, folinic acid and oxaliplatin (FLOX) failed due to several infections, pulmonary embolism and deteriorated performance status. The patient was therefore considered palliative. Palliative treatment with metronomic capecitabine 500 mg x 2 daily and bevacizumab every other week were initiated. After 4 months of treatment the tumors had regressed and the patient was able to undergo radical surgery, thereby changing the treatment intention from palliative to curative. No adjuvant chemotherapy was given. There were no signs of recurrence 9 months later. Conclusions: The role of the combination of metronomic capecitabine and bevacizumab in patients with MAC merits further investigation. Funding Agencies|foundation of Oncological Clinical Research in Linkoping |
| Databáze: | OpenAIRE |
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